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#randomized controlled trial

2 dispatches

• Reading Note

CAR-T Bests Solid Tumors

The promise of immune cell therapies is to direct the incredible sophistication of the immune system to the medical targets we want to hit. In the case of CAR-T cells, we take a patient’s own immune T-cells and “program” them through genetic modification to go after cancer cells. While the process of the genetic modification to create those cells is still incredibly expensive...

• Essay

Real World Effectiveness vs. Clinical Trial Efficacy

Randomized controlled trials (RCTs) are the “gold standard” in healthcare for proving a treatment works. And for good reason. A well-designed and well-powered (i.e., large enough) clinical trial establishes what is really due to a treatment as opposed to another factor (e.g., luck, reversion to the mean, patient selection, etc.), and it’s a good thing that drug regulation is...